CARS operates within the safety regulations of The University of Chicago, the U.S. Department of Energy, Argonne National Laboratory, and the APS itself, supplemented where appropriate by guidelines from other agencies or safety authorities.

Each user experiment is reviewed by the APS and beamline staff for potential safety issues (see the New Users page, step 5), and work may not begin until this review has been completed.

The Executive Director of CARS is responsible for the safe operation of the CARS beamlines and the associated experimental facilities. The CARS Safety Committee advises the Executive Director on the development of safe operating procedures for beamline operation and other day-to-day safety requirements. It is composed of members appointed by the Executive Director. The committee also responds to the safety concerns of CARS members and staff.

The following are references governing safe operation at CARS: